Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: Linking cardiometabolic and neuropsychiatric diseases
نویسندگان
چکیده
منابع مشابه
Brain-derived neurotrophic factor and neuropsychiatric disorders.
Brain derived neurotrophic factor (BDNF) is the most prevalent growth factor in the central nervous system (CNS). It is essential for the development of the CNS and for neuronal plasticity. Because BDNF plays a crucial role in development and plasticity of the brain, it is widely implicated in psychiatric diseases. This review provides a summary of clinical and preclinical evidence for the invo...
متن کاملBrain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases.
Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and perip...
متن کاملAction of brain-derived neurotrophic factor on function and morphology of visual cortical neurons
Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...
متن کاملAction of brain-derived neurotrophic factor on function and morphology of visual cortical neurons
Brain-derived neurotrophic factor (BDNF) is known to play a role in experience-dependent plasticity of the developing visual cortex. For example, BDNF acutely enhances long-term potentiation and blocks long-term depression in the visual cortex of young rats. Such acute actions of BDNF suggested to be mediated mainly through presynaptic mechanisms. A chronic application of BDNF to the visual cor...
متن کاملThe Effect of Endurance Exercise Training on the Expression of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) Genes of the Cerebellum in Diabetic Rat
Objective: Few studies have been conducted on variations of the central nervous system of diabetic patients and much fewer investigations done on the cerebellum of diabetes patients. The current research aims to investigate the effect of endurance training on neurotrophic factors affecting the cerebellum in the diabetic rat. Materials and Methods: This study is experimental.Twenty Wistar rat w...
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ژورنال
عنوان ژورنال: World Journal of Pharmacology
سال: 2013
ISSN: 2220-3192
DOI: 10.5497/wjp.v2.i4.92